ALPI
Description
The ALPI (alkaline phosphatase, intestinal) is a protein-coding gene located on chromosome 2.
Alkaline phosphatase, intestinal, also known as ALPI, is a type of alkaline phosphatase encoded by the ALPI gene in humans. This protein is crucial for maintaining gut homeostasis. Its functions include detoxifying bacterial toxins, dephosphorylating nucleotides, regulating lipid absorption in the intestine, and managing the microbiome. Additionally, it can modulate bicarbonate secretion and the pH of the duodenum.
Alkaline phosphatase that can hydrolyze various phosphate compounds.
ALPI is also known as IAP.
Associated Diseases
- refractive error
- type 2 diabetes mellitus
- hypertriglyceridemia 2
- cholesterol-ester transfer protein deficiency
- obesity due to melanocortin 4 receptor deficiency
- hyperlipidemia due to hepatic triglyceride lipase deficiency
- hypoalphalipoproteinemia, primary, 1
- congenital diarrhea 7 with exudative enteropathy
