ALG10

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Description

The ALG10 (ALG10 alpha-1,2-glucosyltransferase) is a protein-coding gene located on chromosome 12.

The ALG10 gene encodes a membrane-bound protein that plays a vital role in the process of N-linked glycosylation. It acts as an alpha-1,2-glucosyltransferase, specifically adding the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. This enzyme transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. Interestingly, the rat homolog of this protein has been shown to modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel.

Adds the third and final glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. This enzyme transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.

ALG10 is also known as ALG10A, DIE2, KCR1.

Associated Diseases

• hearing loss, autosomal recessive
• autosomal dominant nonsyndromic hearing loss 7
• autosomal dominant nonsyndromic hearing loss 17
• deafness, aminoglycoside-induced
• autosomal dominant nonsyndromic hearing loss
• autosomal recessive nonsyndromic hearing loss 1B
• hearing loss, autosomal recessive 110
• autosomal dominant nonsyndromic hearing loss 40
• hearing loss, autosomal recessive 117
• hearing loss, autosomal dominant 74
• hearing loss, autosomal dominant 83
• autosomal dominant nonsyndromic hearing loss 3B
• hearing loss, sensorineural, autosomal-mitochondrial type