ALDOC
Description
The ALDOC (aldolase, fructose-bisphosphate C) is a protein-coding gene located on chromosome 17.
Aldolase C, fructose-bisphosphate (ALDOC, or ALDC), is an enzyme encoded by the ALDOC gene on chromosome 17. It belongs to the class I fructose-bisphosphate aldolase gene family. ALDOC is expressed specifically in the hippocampus and Purkinje cells of the brain. The encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose 1,6-bisphosphate and fructose-1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde 3-phosphate or glyceraldehyde, respectively. ALDOC is one of the three aldolase isozymes (A, B, and C), encoded by three different genes. The amino acid sequence of ALDOC is highly similar to those of the other isozymes, sharing a 68% identity with ALDOB and 78% identity with ALDOA. The active site of all three isozymes is located in the center of the homotetrameric αβ-barrel structure. However, several structural details distinguish ALDOC from the other isozymes. For instance, the Arg303 residue in ALDOC adopts an intermediate conformation between the liganded and unliganded structures observed in the other isozymes. Additionally, the C-terminal region between Glu332 and Lys71 forms a salt bridge with the barrel region that is absent in the A and B isoforms. The electrostatic surface of ALDOC is more negatively charged, which may serve as an acidic binding site or a docking site to accommodate the C-terminal conformations. Four ALDOC-specific residues (N90, V92, R96 and D100) may be key for ALDOC-specific functions.
ALDOC is also known as ALDC.
Associated Diseases
- breast cancer
- hypertriglyceridemia 2
- glioblastoma
- cholesterol-ester transfer protein deficiency
- hyperlipidemia due to hepatic triglyceride lipase deficiency
- homozygous familial hypercholesterolemia
- hypoalphalipoproteinemia, primary, 1
- pancreatic triacylglycerol lipase deficiency
- thyroid hormone metabolism, abnormal, 2
- sitosterolemia
- glycogen storage disease III
- familial apolipoprotein C-II deficiency
- glycogen storage disease VI
- hypercholesterolemia, autosomal dominant, 3
