ALDH3B1
Description
The ALDH3B1 (aldehyde dehydrogenase 3 family member B1) is a protein-coding gene located on chromosome 11.
ALDH3B1 is an enzyme that plays a role in detoxifying aldehydes produced during alcohol metabolism and lipid peroxidation. It is encoded by the ALDH3B1 gene, which spans 20 kb of genomic DNA and consists of 9 coding exons. This gene produces a single 2.8 kb transcript that is highly expressed in kidney and lung. The exact function of ALDH3B1 and the cellular location of its product are currently unknown. Two transcript variants encoding different isoforms have been identified for this gene.
ALDH3B1 primarily oxidizes medium and long chain saturated and unsaturated aldehydes, including benzaldehyde. It exhibits low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde, and may not metabolize short chain aldehydes. ALDH3B1 can utilize both NADP+ and NAD+ as electron acceptors, and is thought to play a protective role against the cytotoxicity caused by lipid peroxidation.
ALDH3B1 is also known as ALDH4, ALDH7.
