AKTIP
Description
The AKTIP (AKT interacting protein) is a protein-coding gene located on chromosome 16.
AKTIP (AKT-interacting protein) is a protein encoded by the AKTIP gene in humans. In mice, mutations in the AKTIP homolog lead to fused toes, thymic hyperplasia, and early embryonic lethality, suggesting a role in apoptosis. AKTIP lacks a conserved cysteine residue found in ubiquitin-conjugating enzymes but shares similarity with their ubiquitin ligase domain. It directly interacts with AKT1, modulating its activity by promoting phosphorylation at regulatory sites. Alternative splicing generates two transcript variants encoding the same protein.
The AKTIP protein is a component of the FTS/Hook/FHIP complex (FHF complex), which plays a role in vesicle trafficking and fusion by interacting with the homotypic vesicular protein sorting complex (HOPS complex). AKTIP regulates apoptosis by activating AKT1, leading to increased release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling pathway. The FHF complex also contributes to the distribution of the AP-4 complex to the perinuclear region of the cell.
AKTIP is also known as FT1, FTS.
