AKAP9
Description
The AKAP9 (A-kinase anchoring protein 9) is a protein-coding gene located on chromosome 7.
A-kinase anchor protein 9 is a protein that in humans is encoded by the AKAP9 gene. AKAP9 is also known as Centrosome- and Golgi-localized protein kinase N-associated protein (CG-NAP) or AKAP350 or AKAP450
== Function == The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in many isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3.
== Interactions == AKAP9 has been shown to interact with:
== References ==
== Further reading ==
== External links == AKAP9 human gene location in the UCSC Genome Browser. AKAP9 human gene details in the UCSC Genome Browser. This article incorporates text from the United States National Library of Medicine, which is in the public domain.
AKAP9, a scaffolding protein, assembles various protein kinases and phosphatases at the centrosome and Golgi apparatus. It plays a critical role in maintaining Golgi apparatus integrity (PubMed:10202149, PubMed:15047863), facilitating microtubule nucleation at the Golgi's cis-side (PubMed:15047863, PubMed:19242490), and ensuring proper centrosome attachment to the bipolar mitotic spindle poles during metaphase (PubMed:25657325). Working in conjunction with PDE4DIP isoform 13/MMG8/SMYLE, AKAP9 recruits CAMSAP2 to the Golgi, anchoring non-centrosomal minus-end microtubules to the Golgi - a crucial step in polarized cell movement (PubMed:27666745, PubMed:28814570). In association with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1, and CDK5RAP2, it participates in microtubule nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). {ECO:0000269|PubMed:10202149, ECO:0000269|PubMed:15047863, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}
AKAP9 is also known as AKAP-9, AKAP350, AKAP450, CG-NAP, HYPERION, LQT11, MU-RMS-40.16A, PPP1R45, PRKA9, YOTIAO.
