AKAP2
Description
AKAP2, or A-kinase anchoring protein 2, is a scaffolding protein that plays a crucial role in regulating cardiac function. It acts as a molecular hub, organizing signaling pathways that control processes such as calcium handling, contractility, and electrical activity within heart cells. AKAP2 achieves this by binding to and localizing various signaling molecules, including protein kinase A (PKA), protein phosphatase 2B (PP2B), and phosphodiesterases, thereby controlling their activity and interactions. Dysregulation of AKAP2 has been implicated in the pathogenesis of various heart diseases, highlighting its significance in maintaining cardiac health.
Associated Diseases
Did you know?
AKAP2 is found not only in the heart but also in other tissues, including the brain and skeletal muscle, suggesting its diverse roles in cellular regulation.
