AKAP12
Description
The AKAP12 (A-kinase anchoring protein 12) is a protein-coding gene located on chromosome 6.
AKAP12, also known as AKAP250, is an enzyme encoded by the AKAP12 gene in humans. AKAPs (A-kinase anchor proteins) are a diverse group of proteins that bind to the regulatory subunit of protein kinase A (PKA), anchoring the holoenzyme to specific locations within the cell. AKAP12 is a member of this family and is expressed in endothelial cells, fibroblasts, and osteosarcoma cells. It associates with protein kinase A and C, as well as phosphatase, acting as a scaffold protein in signal transduction. AKAP12 and RII PKA are found together at the cell periphery, and AKAP12 is involved in cell growth. Antibodies against AKAP12 can be produced by patients with myasthenia gravis. Two transcript variants encoding different isoforms are produced through alternative splicing of the AKAP12 gene. AKAP12 has been shown to interact with the Beta-2 adrenergic receptor.
AKAP12 is an anchoring protein that helps to regulate the location of protein kinase A (PKA) and protein kinase C (PKC) within cells.
AKAP12 is also known as AKAP250, SSeCKS.
