AKAP10
Description
The AKAP10 (A-kinase anchoring protein 10) is a protein-coding gene located on chromosome 17.
AKAP10 is a protein that binds to the regulatory subunit of protein kinase A (PKA), confining the enzyme to specific locations within the cell. It is found primarily in mitochondria and can bind to both type I and type II regulatory subunits of PKA. It contains RGS domains, which may have important implications for its function in PKA and G protein signal transduction. AKAP10 interacts with proteins like PDZK1 and PRKAR1A.
AKAP10 is a protein that can bind to both type I and type II regulatory subunits of protein kinase A (PKA), anchoring them to mitochondria or the plasma membrane. Its role in mitochondrial PKA signaling is not fully understood, but it may inactivate the pro-apoptotic protein BAD by phosphorylation. Additionally, AKAP10 could facilitate PKA and G protein signal transduction by acting as an adapter for multiprotein complexes. Its RGS domain allows interaction with G-alpha proteins, potentially connecting signaling pathways to downstream kinases.
AKAP10 is also known as AKAP-10, D-AKAP-2, D-AKAP2, PRKA10.
