AKAP1
Description
The AKAP1 (A-kinase anchoring protein 1) is a protein-coding gene located on chromosome 17.
AKAP1 (A-kinase anchor protein 1, mitochondrial) is an enzyme encoded by the AKAP1 gene in humans. AKAPs are proteins that bind to the regulatory subunit of protein kinase A (PKA) and tether the enzyme to specific cellular locations. AKAP1 anchors PKA to the mitochondrion. This protein is thought to be involved in the cAMP-dependent signal transduction pathway and RNA trafficking.
AKAP1 binds to the regulatory subunits of protein kinase A (PKA) and anchors them to the mitochondrial outer membrane. It plays a role in antiviral immunity by mediating mitochondrial responses. AKAP1 also facilitates the transport of NDUFS1 into mitochondria, which regulates the activity of the NADH dehydrogenase (Complex I) in the respiratory chain.
AKAP1 is also known as AKAP, AKAP121, AKAP149, AKAP84, D-AKAP1, PPP1R43, PRKA1, SAKAP84, TDRD17.
