AHSP

Description

The AHSP (alpha hemoglobin stabilizing protein) is a protein-coding gene located on chromosome 16.

AHSP acts as a chaperone protein during erythroid cell development, preventing harmful aggregation of alpha-hemoglobin. It specifically protects free alpha-hemoglobin from precipitation and is predicted to play a role in modulating pathological conditions of excess alpha-hemoglobin, such as beta-thalassemia.

AHSP is also known as EDRF, ERAF.

Associated Diseases

• alpha thalassemia-intellectual disability syndrome type 1
• hemoglobin D disease
• hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
• hemoglobin E-beta-thalassemia syndrome
• dominant beta-thalassemia
• hemolytic anemia due to adenylate kinase deficiency
• delta-beta-thalassemia
• Heinz body anemia
• alpha-thalassemia-myelodysplastic syndrome
• beta-thalassemia-X-linked thrombocytopenia syndrome
• hemoglobin C-beta-thalassemia syndrome
• hemoglobin E disease
• hemoglobin H disease
• hemolytic anemia due to erythrocyte adenosine deaminase overproduction