AHRR

Description

The AHRR (aryl hydrocarbon receptor repressor) is a protein-coding gene located on chromosome 5.

AHRR refers to the human gene AHRR, which encodes a protein involved in various cellular functions, particularly in response to environmental toxins.

AHRR plays a crucial role in mediating dioxin toxicity and regulating cell growth and differentiation. It acts as a repressor of the transcription factor AHR, competing for binding to the ARNT protein and ultimately preventing AHR from binding to the xenobiotic response element (XRE) in the promoter regions of various genes. This repression also extends to the CYP1A1 gene, where AHRR binds to the XRE sequence and recruits proteins like ANKRA2, HDAC4, and HDAC5 to further suppress transcription. Moreover, AHRR exhibits autoregulation, binding to its own XRE site and controlling its own expression levels.

AHRR is also known as AHH, AHHR, bHLHe77.

Associated Diseases

• prostate cancer
• X-linked retinal dysplasia
• hereditary persistence of fetal hemoglobin-sickle cell disease syndrome