AGTRAP

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Description

The AGTRAP (angiotensin II receptor associated protein) is a protein-coding gene located on chromosome 1.

AGTRAP (angiotensin II receptor-associated protein) is a human gene that encodes a transmembrane protein found in the plasma membrane and perinuclear vesicles. This protein interacts with the angiotensin II type I receptor and inhibits angiotensin II signaling. Alternative splicing of the gene generates various transcript variants leading to different isoforms. AGTRAP is known to interact with GNB2L1.

AGTRAP negatively regulates type-1 angiotensin II receptor-mediated signaling by influencing receptor internalization and desensitization mechanisms, such as phosphorylation. It also reduces cell proliferation and angiotensin II-stimulated gene expression.

AGTRAP is also known as ATRAP.

Associated Diseases

• cancer
• endometrial cancer
• familial idiopathic steroid-resistant nephrotic syndrome
• obesity due to melanocortin 4 receptor deficiency
• PLIN1-related familial partial lipodystrophy
• glomerulopathy with fibronectin deposits 2
• LIPE-related familial partial lipodystrophy
• CIDEC-related familial partial lipodystrophy
• nail-patella-like renal disease
• hemoglobin D disease
• focal segmental glomerulosclerosis 5
• X-linked sideroblastic anemia 1
• adenine phosphoribosyltransferase deficiency
• autosomal dominant progressive nephropathy with hypertension