AGTR2

Description

The AGTR2 (angiotensin II receptor type 2) is a protein-coding gene located on chromosome X.

Angiotensin II receptor type 2, also known as the AT2 receptor is a protein that in humans is encoded by the AGTR2 gene. Angiotensin II is a potent pressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors termed AT1 and AT2. AGTR2 belongs to a family 1 of G protein-coupled receptors. It is an integral membrane protein. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin–angiotensin system. This receptor mediates programmed cell death (apoptosis). Consistent with its apoptotic function, angiotensin II receptor type II also opposes cell proliferation, as demonstrated by its antagonism of MAPK activity in cardiac fibroblasts during interstitial fibrosis. In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube.

Receptor for angiotensin II, a vasoconstricting peptide. Signals primarily via a non-canonical G-protein- and beta-arrestin independent pathways. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.

AGTR2 is also known as AT2, ATGR2, MRX88.

Associated Diseases

• ovarian cancer
• low grade glioma
• postherpetic neuralgia
• familial idiopathic steroid-resistant nephrotic syndrome
• pentosuria
• uridine-cytidineuria
• isolated sedoheptulokinase deficiency
• nail-patella-like renal disease
• glioblastoma
• left ventricular noncompaction
• primary hyperoxaluria type 3
• primary hyperoxaluria type 2