AGMAT
Description
The AGMAT gene encodes for agmatinase, an enzyme crucial for the breakdown of agmatine, a bioactive polyamine. Agmatinase catalyzes the conversion of agmatine to putrescine, a precursor to other polyamines like spermidine and spermine. These polyamines play vital roles in various cellular processes, including cell growth, proliferation, and differentiation. AGMAT expression is tightly regulated, and its dysregulation is linked to several health conditions.
Associated Diseases
- Cancer (e.g., prostate cancer, colorectal cancer)
- Neurological disorders (e.g., Alzheimer's disease, Parkinson's disease)
- Cardiovascular diseases (e.g., hypertension, atherosclerosis)
- Inflammatory diseases (e.g., rheumatoid arthritis)
- Metabolic disorders (e.g., diabetes, obesity)
Did you know?
Agmatine has been shown to exhibit neuroprotective properties, potentially acting as a modulator of neuronal signaling.
