AFAP1-AS1

afap1-as1: An Intriguing Long Non-Coding RNA with Far-Reaching Implications

Description:

afap1-as1 is a newly discovered long non-coding RNA (lncRNA) with a length of approximately 1.4 kilobases. Unlike protein-coding genes, lncRNAs do not produce proteins but instead play crucial roles in regulating gene expression and cellular processes. afap1-as1 is located on chromosome 1 and is primarily expressed in the nucleus of cells.

Associated Diseases:

Research has implicated afap1-as1 in the development and progression of several diseases, including:

  • Gastrointestinal Cancers: afap1-as1 has been found to be overexpressed in gastric and colorectal cancers. Its overexpression promotes cancer cell proliferation, migration, and invasion.

  • Hepatocellular Carcinoma: afap1-as1 overexpression has been linked to poor prognosis in hepatocellular carcinoma. It enhances tumor growth and metastasis by influencing cell cycle regulation.

  • Breast Cancer: Studies have shown that afap1-as1 is upregulated in breast cancer and is associated with resistance to chemotherapy.

Did you Know ?

Overexpression of afap1-as1 in gastric cancer is associated with a 2.5-fold increased risk of metastasis.


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