ADRB2
Adrb2: A Key Receptor in Asthma and Beyond
Description
Adrb2 (beta-2 adrenergic receptor) is a G protein-coupled receptor (GPCR) that plays a crucial role in the regulation of various physiological processes. It is primarily found in the airway smooth muscle and lungs but is also expressed in other tissues such as the heart, liver, and immune cells.
Adrb2 is activated by binding to catecholamines, including epinephrine (adrenaline) and norepinephrine (noradrenaline). Upon activation, Adrb2 initiates a signaling cascade that leads to increased levels of cyclic adenosine monophosphate (cAMP), which in turn inhibits smooth muscle contraction.
Associated Diseases
Asthma: Adrb2 is a major therapeutic target for asthma, a chronic inflammatory airway disease characterized by wheezing, coughing, and shortness of breath. Impaired Adrb2 function or expression can lead to airway hyperresponsiveness and increased susceptibility to asthma attacks.
Other Associated Diseases:
- Chronic obstructive pulmonary disease (COPD)
- Bronchitis
- Emphysema
- Cardiovascular diseases
- Hypertension
- Diabetes
- Obesity
Did you Know ?
Approximately 10-20% of asthmatics have a defect in the Adrb2 gene, leading to reduced receptor activity and contributing to the severity of their disease.
