ADRA1A
Unlocking the Secrets of α1A-Adrenergic Receptor
Description:
α1A-Adrenergic receptor (α1A-AR) is a subtype of adrenergic receptor, a class of cell surface receptors that respond to catecholamines, such as epinephrine and norepinephrine. These receptors play a critical role in various physiological processes, including blood pressure regulation, heart rate, and smooth muscle contraction.
α1A-AR is primarily expressed in the postsynaptic membrane of smooth muscle cells, where it mediates the vasoconstrictive effects of catecholamines. It is also found in the central nervous system, where it regulates neurotransmission and behavior.
Associated Diseases:
Dysregulation of α1A-AR has been implicated in a wide range of diseases and conditions, including:
- Hypertension: α1A-AR overactivity can lead to increased vascular tone and elevated blood pressure.
- Asthma and chronic obstructive pulmonary disease (COPD): α1A-AR constricts airway smooth muscle, contributing to airway obstruction in these conditions.
- Urinary incontinence: α1A-AR in the bladder neck regulates urine flow and can lead to incontinence when malfunctioning.
- Attention deficit hyperactivity disorder (ADHD): Studies suggest that α1A-AR underactivity may contribute to symptoms of ADHD.
Did you Know ?
α1A-AR is the most abundant adrenergic receptor subtype in the human cardiovascular system, highlighting its crucial role in blood pressure regulation.
