ADI1

---

The ADI1 gene (Acireductone Dioxygenase 1) encodes an enzyme involved in the methionine salvage pathway, a process that recycles methionine from 5‘-methylthioadenosine. This enzyme plays a crucial role in various cellular processes, including mRNA processing and regulation of cell migration.

Associated Diseases:

While research on the direct association between the ADI1 gene and specific diseases is ongoing, studies have suggested its potential involvement in the following:

1. Cancer:

   • Pancreatic Cancer: Research suggests that ADI1 may act as a tumor suppressor in pancreatic cancer. Downregulation of ADI1 has been observed in pancreatic tumor cells, and restoring its expression has been shown to inhibit tumor cell metastasis.

2. Neurological Disorders:

   • Alzheimer‘s Disease: Some studies have indicated a potential link between variations in the ADI1 gene and an increased risk of Alzheimer‘s disease. However, more research is needed to confirm this association.

3. Other Conditions:

   • Methionine Metabolism Disorders: Given its role in the methionine salvage pathway, dysregulation of the ADI1 gene may contribute to disorders related to methionine metabolism.