ADH7
The ADH7 gene (Alcohol Dehydrogenase 7) is responsible for encoding an enzyme involved in the metabolism of alcohol. This enzyme is primarily found in the stomach mucosa and plays a role in the early stages of alcohol metabolism before its absorption into the bloodstream.
Associated Diseases:
While research on the direct association between the ADH7 gene and specific diseases is still ongoing, studies have suggested its potential involvement in the following:
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Cancer:
- Upper Aerodigestive Tract Cancers: Some studies have found an association between certain variations (polymorphisms) in the ADH7 gene and an increased risk of cancers in the upper aerodigestive tract, including the mouth, pharynx, larynx, and esophagus.
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Pain:
- Sickle Cell Disease: Research suggests that a specific ADH7 gene polymorphism might be associated with both acute and chronic pain in individuals with sickle cell disease.
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Other Conditions:
- Alcohol Dependence: Some studies have explored a potential link between ADH7 gene variations and alcohol dependence. However, the findings are not conclusive and require further investigation.
- Schizophrenia: A study in the Han Chinese population found a potential association between an ADH7 gene polymorphism and schizophrenia.
- Gastric Cancer: Changes in the activity of the enzyme encoded by ADH7 have been observed in the sera of patients with gastric cancer, but the exact significance of this finding is not fully understood.
Further Research:
The exact mechanisms by which ADH7 contributes to these diseases are still under investigation. Further research is necessary to clarify the role of the ADH7 gene in disease development, progression, and potential therapeutic implications.
