ADH6
Alzheimer‘s Disease and the ADH6 Gene: A Comprehensive Exploration
Description
Alzheimer‘s disease (AD) is a neurodegenerative disorder that affects millions of people worldwide. It is characterized by progressive memory loss, cognitive decline, and behavioral changes. Research has identified several genetic factors that contribute to the development of AD, including the ADH6 gene.
ADH6 encodes alcohol dehydrogenase class 6, an enzyme that metabolizes alcohol and other substances. Variants in the ADH6 gene have been associated with an increased risk of developing AD. One particular variant, rs2238607, has been extensively studied for its role in AD pathogenesis.
Associated Diseases
In addition to AD, variants in the ADH6 gene have also been linked to:
- Vascular dementia: A type of dementia caused by reduced blood flow to the brain.
- Parkinson‘s disease: A neurodegenerative disorder that affects movement and causes tremors, stiffness, and balance problems.
- Multiple sclerosis: A chronic autoimmune disease that affects the central nervous system.
Did you Know ?
Studies have shown that individuals with a certain genotype of the ADH6 gene have a significantly increased risk of developing AD. Specifically, the presence of the rs2238607 variant has been associated with a 30-50% increased risk of AD compared to individuals without the variant.
