ADGRG5
ADGRG5: A Comprehensive Overview
Introduction
ADGRG5, also known as adhesion G protein-coupled receptor G5, is a protein involved in cell adhesion and signaling. It is located on the cell surface and plays a crucial role in regulating cell-cell interactions, cell migration, and tissue development.
Description
ADGRG5 is a member of the adhesion G protein-coupled receptor (GPCR) family. These receptors are characterized by having an extracellular domain that binds to specific ligands, a transmembrane domain, and an intracellular domain that interacts with G proteins. ADGRG5 specifically binds to several ligands, including fibronectin, vitronectin, and tenascin-C.
Associated Diseases
Dysregulation of ADGRG5 has been implicated in various diseases, including:
- Epilepsy: ADGRG5 is highly expressed in the hippocampus, a brain region involved in memory and learning. Mutations in ADGRG5 have been linked to an increased risk of developing epilepsy.
- Cancer: ADGRG5 is involved in cell migration and adhesion, processes that are essential for tumor progression. Overexpression of ADGRG5 has been observed in several types of cancer, including breast cancer, lung cancer, and melanoma.
- Inflammatory bowel disease: ADGRG5 is expressed on immune cells and plays a role in regulating immune responses. Dysregulation of ADGRG5 has been implicated in the development of inflammatory bowel disease, such as Crohn‘s disease and ulcerative colitis.
Did you Know ?
- Approximately 1 in 200 people worldwide have a mutation in the ADGRG5 gene that increases their risk of developing epilepsy.
