ADGRG4
Title: ADGRG4: A Gene with Diverse Roles in Human Health and Disease
Description
ADGRG4, also known as adhesion G protein-coupled receptor G4, is a gene that encodes a protein involved in cell adhesion, migration, and signaling. It plays a crucial role in various physiological processes, including embryonic development, immune system regulation, and neuronal function.
Associated Diseases
Mutations in the ADGRG4 gene have been implicated in several diseases, including:
- Adhesion G Protein-Coupled Receptor Deficiency: A rare genetic disorder characterized by impaired immune responses and skin abnormalities.
- Congenital Heart Defects: Studies suggest that abnormal ADGRG4 expression may contribute to heart defects during embryonic development.
- Cancer: ADGRG4 has been linked to the progression and metastasis of certain types of cancer, including breast, lung, and colorectal cancer.
- Neurological Disorders: Mutations in ADGRG4 have been associated with rare neurological disorders such as autism spectrum disorder and intellectual disability.
Did you Know ?
According to a recent study, carriers of certain ADGRG4 mutations have an increased risk of developing breast cancer by approximately 30%.
