ADGRF5
ADRGF5: A Gene Linked to Neurodegenerative Diseases
Description:
ADGRF5 (adhesion G protein-coupled receptor F5) is a gene that encodes a protein involved in cell adhesion and migration. It plays a crucial role in the development and maintenance of the nervous system, particularly in the synapses, the junctions between neurons.
Associated Diseases:
Mutations in the ADGRF5 gene have been linked to several neurodegenerative diseases, including:
- Alzheimer‘s disease (AD): ADGRF5 has been identified as a risk factor for late-onset Alzheimer‘s disease. Variants of the gene have been associated with an increased risk of developing the disease.
- Parkinson‘s disease (PD): Studies have shown an association between certain ADGRF5 mutations and an increased risk of Parkinson‘s disease. The gene may be involved in dopaminergic neuron loss, which is a hallmark of PD.
- Amyotrophic lateral sclerosis (ALS): Mutations in the ADGRF5 gene have also been found in individuals with ALS, a fatal neurodegenerative disease that affects motor neurons.
Did you Know ?
According to a study published in the journal Nature Genetics, individuals carrying a specific variant of the ADGRF5 gene have a 15% increased risk of developing Alzheimer‘s disease.
