ADGRF2
Title: Adgrf2: A Receptor with a Vital Role in Heart Development and Function
Introduction:
Adgrf2, also known as GPR116, is a G protein-coupled receptor (GPCR) that plays a crucial role in heart development and function. This receptor has been implicated in regulating cardiac valve formation, ion homeostasis, and heart rate. Understanding the function of Adgrf2 is essential for unraveling the mysteries of heart disease and developing novel therapeutic strategies.
Description:
Adgrf2 is a cell surface receptor that belongs to the adhesion GPCR family. It is expressed predominantly in the heart, specifically in cardiomyocytes and endothelial cells. The receptor binds to various ligands, including growth factors, extracellular matrix proteins, and hormones, triggering intracellular signaling pathways that regulate cardiac development and function.
Associated Diseases:
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Congenital Heart Defects: Mutations in Adgrf2 have been associated with congenital heart defects, such as bicuspid aortic valve and ventricular septal defects. These defects arise from impaired cardiac valve formation and disrupted heart development.
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Arrhythmias: Adgrf2 has been implicated in regulating heart rate and rhythm. Dysfunction of the receptor can lead to arrhythmias, including atrial fibrillation and ventricular tachycardia.
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Heart Failure: Studies have suggested that Adgrf2 may play a role in the development of heart failure. Dysregulation of the receptor can disrupt cardiac function and contribute to the progression of heart failure.
Did you Know ?
- Approximately 1 in 200 individuals worldwide is affected by congenital heart defects, and mutations in Adgrf2 are estimated to account for a small percentage of these cases.
