ADGRF1
ADGRF1: The Adhesion G Protein-Coupled Receptor F1
Description:
ADGRF1, also known as GPR116, is an adhesion G protein-coupled receptor (GPCR) protein that plays a crucial role in various physiological processes. It is expressed on the surface of endothelial cells, platelets, and immune cells. ADGRF1 acts as a receptor for adhesion molecules, such as VCAM-1, and triggers intracellular signaling pathways that influence cell migration, inflammation, and thrombosis.
Associated Diseases:
Dysregulation of ADGRF1 expression or function has been implicated in several diseases, including:
- Cardiovascular disease: ADGRF1 promotes platelet aggregation and vascular inflammation, contributing to the development of atherosclerosis and thrombosis.
- Autoimmune disorders: Excessive ADGRF1 signaling in immune cells can lead to increased inflammation and tissue damage, as observed in rheumatoid arthritis and inflammatory bowel disease.
- Cancer: ADGRF1 expression is often elevated in tumor cells, facilitating their migration and invasion. It has been associated with poor prognosis in cancers such as breast, colon, and lung cancer.
Did you Know ?
Studies have shown that polymorphisms in the ADGRF1 gene are associated with an increased risk of cardiovascular disease and type 2 diabetes. For instance, one study found that individuals carrying a specific variant of the ADGRF1 gene had a 25% higher risk of developing coronary artery disease.
