ADGRE5
Description
ADGRE5, also known as EMR2, encodes a transmembrane protein that plays a crucial role in immune cell signaling and regulation. It belongs to the adhesion G protein-coupled receptor family, a group of proteins that are involved in cell-cell interactions and signal transduction. ADGRE5 is predominantly expressed on immune cells, such as macrophages, neutrophils, and dendritic cells, where it interacts with various ligands, including extracellular matrix components and other cell surface molecules. This interaction triggers signaling pathways that influence immune cell activation, migration, and cytokine production. ADGRE5 is therefore a vital component of the intricate network of immune responses.
Associated Diseases
- Autoimmune diseases: ADGRE5 is linked to the development of autoimmune disorders like rheumatoid arthritis and systemic lupus erythematosus.
- Inflammatory bowel disease (IBD): Studies have implicated ADGRE5 in the pathogenesis of IBD, suggesting its role in regulating inflammatory processes in the gut.
- Cancer: Altered expression of ADGRE5 has been observed in certain cancers, indicating a potential link to tumor development and progression.
Did you know?
ADGRE5 is involved in the recognition and response to microbial pathogens, playing a key role in the innate immune system‘s defense against infections.
