ADGRE1
Title: ADGRE1: A Gene with Diverse Roles in Health and Disease
Description:
ADGRE1 (adhesion G protein-coupled receptor E1) is a gene that encodes a protein of the same name. This protein plays a crucial role in various cellular processes, including cell adhesion, migration, and signaling. Mutations in the ADGRE1 gene have been linked to a range of diseases, including cancer, autoimmune disorders, and neurodevelopmental disorders.
Associated Diseases:
- Cancer: Mutations in ADGRE1 have been implicated in the development of several types of cancer, including breast cancer, lung cancer, and colorectal cancer. These mutations often lead to the loss of normal ADGRE1 function, which can promote tumor growth and metastasis.
- Autoimmune disorders: ADGRE1 is involved in the regulation of immune responses. Mutations in this gene can disrupt immune function and lead to autoimmune disorders such as rheumatoid arthritis, systemic lupus erythematosus, and type 1 diabetes.
- Neurodevelopmental disorders: ADGRE1 plays a role in neuronal development and function. Mutations in this gene have been associated with neurodevelopmental disorders such as autism spectrum disorder and intellectual disability.
Did you Know ?
According to a study published in the journal Nature Genetics, mutations in ADGRE1 are found in approximately 0.5% of individuals with autism spectrum disorder. This suggests that ADGRE1 plays a significant role in the development of this disorder.
