ADGRD1
ADGRD1: A Comprehensive Guide
Introduction
ADGRD1, also known as adhesion G protein-coupled receptor D1, is a gene that encodes a protein involved in cell adhesion and migration. Its function is crucial for several physiological processes, including immune responses, tissue development, and wound healing. Mutations in the ADGRD1 gene can lead to various diseases and conditions.
Description
The ADGRD1 protein is a member of the adhesion G protein-coupled receptor (GPCR) family, characterized by their ability to bind to both extracellular ligands and intracellular G proteins. It is expressed on the surface of immune cells, particularly monocytes and macrophages, and plays a role in regulating their migration and adhesion to endothelial cells.
Associated Diseases
Mutations in the ADGRD1 gene have been linked to several diseases and conditions, including:
- HIV infection: ADGRD1 is a co-receptor for HIV-1, facilitating the virus‘s entry into immune cells.
- Arthritis: ADGRD1 is involved in regulating immune cell migration and inflammation in arthritis.
- Cancer: ADGRD1 expression is altered in various cancers, affecting tumor cell migration and metastasis.
- Autoimmune diseases: Mutations in ADGRD1 have been associated with autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis.
Did you Know ?
According to a study published in the journal Nature Genetics, a variant of the ADGRD1 gene is associated with a reduced risk of developing severe COVID-19 infections. The study found that individuals carrying the protective variant had a lower likelihood of hospitalization or death from COVID-19 compared to those without the variant.
