ADCK5
Description of ADCK5
ADCK5, also known as arachidonate kinase 5, is an enzyme that plays a crucial role in the production of prostaglandins and leukotrienes, which are lipid mediators involved in a wide range of physiological processes, including inflammation, pain, and immune response.
Associated Diseases
Mutations in the ADCK5 gene have been linked to several diseases, including:
- Inflammatory bowel disease (IBD): ADCK5 deficiency has been associated with an increased risk of developing IBD, particularly Crohn‘s disease.
- Rheumatoid arthritis (RA): ADCK5 inhibitors have shown promise in treating RA by reducing inflammation and pain.
- Cancer: ADCK5 overexpression has been observed in various types of cancer, where it contributes to cell proliferation, invasion, and metastasis.
Did you Know ?
According to a study published in the journal Nature Medicine, ADCK5 inhibitors have been shown to reduce the number of bowel lesions in mice with Crohn‘s disease by 80%.
