ADCK2
Title: ADCK2: A Pivotal Enzyme in Metabolic Health and Disease
Description:
ADCK2, also known as the adenosine kinase 2 gene, encodes an enzyme crucial for cellular energy metabolism. It catalyzes the conversion of adenosine into adenosine monophosphate (AMP), the first step in the adenine nucleotide salvage pathway. ADCK2 plays a vital role in maintaining cellular energy homeostasis and in regulating the production of adenosine triphosphate (ATP), the energy currency of the cell.
Associated Diseases:
Alterations in ADCK2 function or expression have been linked to various diseases, including:
- Metabolic Syndrome: ADCK2 deficiency disrupts cellular energy metabolism, leading to insulin resistance and impaired glucose tolerance, key features of metabolic syndrome.
- Type 2 Diabetes: Decreased ADCK2 activity in pancreatic beta cells impairs insulin secretion, contributing to the development of type 2 diabetes.
- Neurodegenerative Disorders: ADCK2 dysfunction has been implicated in the pathogenesis of neurodegenerative diseases such as Alzheimer‘s and Parkinson‘s, where it affects energy metabolism and oxidative stress.
- Cancer: Dysregulated ADCK2 expression has been observed in certain cancers, influencing tumor cell growth and metastasis.
Did you Know ?
Recent studies have shown that individuals with a common ADCK2 gene variant have a significantly increased risk of developing metabolic syndrome compared to those with wild-type alleles.
