ADCK1
ADCK1: A Gene with Far-Reaching Implications
Description
ADCK1 (adenosine kinase 1) is a gene that plays a crucial role in regulating the levels of adenosine in the body. Adenosine is a molecule that acts as a neurotransmitter, modulating a wide range of physiological processes, including sleep, cognition, and cardiovascular function.
ADCK1 converts adenosine into adenosine monophosphate (AMP), effectively reducing the amount of adenosine available in the body. Mutations in the ADCK1 gene can disrupt this process, leading to an imbalance in adenosine levels.
Associated Diseases
Mutations in the ADCK1 gene have been linked to several diseases, including:
- Chronic kidney disease (CKD): Mutations in ADCK1 are associated with an increased risk of developing CKD, a condition characterized by the gradual loss of kidney function.
- Cardiovascular disease: Alterations in ADCK1 have been implicated in the development of cardiovascular diseases, such as coronary artery disease and atherosclerosis.
- Neurological disorders: Mutations in ADCK1 have been linked to neurological disorders, including Parkinson‘s disease and Alzheimer‘s disease.
- Cancer: ADCK1 mutations have been found in certain types of cancer, such as breast cancer and lung cancer.
Did you Know ?
Approximately 1-2% of the population carries a mutation in the ADCK1 gene.
