ADAT1
Adat1: A Protein Connecting Immunity and Metabolism
Description
Adat1 (adenosine deaminase acting on RNA 1) is a protein involved in RNA metabolism, particularly in the regulation of gene expression. It plays a crucial role in various cellular processes, including differentiation, proliferation, and inflammation. Adat1 is expressed in a wide range of tissues and cell types, with varying levels of activity depending on cell type and cellular state.
Associated Diseases
Dysregulation of Adat1 has been implicated in several diseases, including:
- Autoimmune disorders: Rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis
- Metabolic disorders: Type 2 diabetes, obesity
- Neurodegenerative disorders: Alzheimer‘s disease, Parkinson‘s disease
- Cancer: Lung cancer, breast cancer, colon cancer
Alterations in Adat1 levels or activity have been associated with disrupted RNA homeostasis, abnormal immune responses, and impaired metabolism.
Did you Know ?
Studies have shown that individuals with reduced Adat1 expression exhibit an increased risk of developing autoimmune diseases. In patients with rheumatoid arthritis, Adat1 levels are significantly lower than in healthy controls.
