ADAMTS9-AS2
ADAMTS9-AS2: An Intriguing Antisense Gene
Description
ADAMTS9-AS2, also known as ADAM metallopeptidase with thrombospondin type 1 motif, 9 antisense RNA 2, is a non-coding RNA molecule located on chromosome 3q26.2. It is an antisense RNA, meaning it is complementary to the sense strand of the ADAMTS9 gene. ADAMTS9 encodes a protease involved in extracellular matrix remodeling and tissue homeostasis.
ADAMTS9-AS2 plays a crucial role in regulating the expression of ADAMTS9 by binding to its promoter region and inhibiting its transcription. This downregulation of ADAMTS9 has been linked to various cellular processes, including cell proliferation, migration, and apoptosis.
Associated Diseases
Dysregulation of ADAMTS9-AS2 has been implicated in several diseases, including:
- Rheumatoid arthritis: ADAMTS9-AS2 is overexpressed in synovial fibroblasts of rheumatoid arthritis patients, contributing to the excessive production of pro-inflammatory cytokines and tissue destruction.
- Osteoarthritis: Studies suggest that low levels of ADAMTS9-AS2 may lead to increased cartilage degradation and the development of osteoarthritis.
- Cancer: Aberrant expression of ADAMTS9-AS2 has been observed in several types of cancer, including lung, breast, and colon cancer. Its role in cancer progression remains to be fully elucidated.
Did you Know ?
- A study found that high levels of ADAMTS9-AS2 in synovial fluid were associated with a significantly increased risk of disease severity in rheumatoid arthritis patients.
