ADAMTS6
ADAMTS6: A Crucial Enzyme in Health and Disease
Description
ADAMTS6 (A Disintegrin And Metallopeptidase with Thrombospondin type 1 motifs, member 6) is an extracellular metalloprotease enzyme. It plays a critical role in various physiological and pathological processes, including:
- Matrix remodeling
- Tissue development
- Angiogenesis
- Inflammation
ADAMTS6 cleaves specific substrates within the extracellular matrix (ECM), altering its composition and influencing cell behavior. This enzymatic activity is essential for tissue homeostasis, remodeling, and repair.
Associated Diseases
Dysregulation of ADAMTS6 has been implicated in several diseases, including:
- Osteoarthritis: ADAMTS6 is involved in cartilage breakdown, a hallmark of osteoarthritis. Decreased ADAMTS6 levels lead to excessive cartilage degradation, while increased levels contribute to cartilage repair.
- Cardiovascular disease: ADAMTS6 plays a role in the formation and stability of atherosclerotic plaques. Its deficiency leads to increased plaque vulnerability, potentially triggering cardiovascular events.
- Cancer: ADAMTS6 is involved in tumor cell migration, invasion, and angiogenesis. Its overexpression in some cancers is associated with increased tumor aggressiveness and metastasis.
Did you Know ?
ADAMTS6 is one of the most differentially expressed genes in the synovium of patients with rheumatoid arthritis, indicating its significant involvement in joint inflammation and cartilage destruction.
