ADAMTS16
ADAMTS16: A Multifaceted Protein with Diverse Roles in Human Health
Description
ADAMTS16 (A Disintegrin And Metalloproteinase with Thrombospondin Motifs-16) is a secreted glycoprotein that belongs to the ADAMTS family of proteases. It is characterized by a unique domain structure consisting of a prodomain, a catalytic metalloprotease domain, and a C-terminal thrombospondin type 1 domain.
ADAMTS16 is mainly produced by mesenchymal cells, including fibroblasts, chondrocytes, and smooth muscle cells. It plays a pivotal role in extracellular matrix (ECM) remodeling and tissue homeostasis. The protein exhibits enzymatic activity towards various substrates, including aggrecan, versican, and fibronectin.
Associated Diseases
Dysregulation of ADAMTS16 activity has been implicated in several human diseases, including:
- Osteoarthritis (OA): ADAMTS16 is involved in cartilage degradation and inflammation in OA. Increased levels of ADAMTS16 have been associated with cartilage loss and joint pain.
- Cardiovascular disease: ADAMTS16 contributes to vascular remodeling and inflammation. Its deficiency has been linked to abdominal aortic aneurysm and atherosclerosis.
- Cancer: ADAMTS16 has been found to promote tumor growth and angiogenesis. Its overexpression is associated with poor prognosis in certain cancers, such as breast cancer and colorectal cancer.
- Autoimmune diseases: ADAMTS16 is involved in immune cell activation and inflammation. Its dysregulation has been observed in autoimmune diseases, including rheumatoid arthritis and lupus.
Did you Know ?
Research indicates that individuals with a genetic variant in the ADAMTS16 gene have a 2-fold increased risk of developing osteoarthritis. This highlights the potential role of ADAMTS16 in the pathogenesis of this debilitating joint disease.
