ADAMTS14
ADAMTS14: The Matrix Metallopeptidase with Diverse Roles in Health and Disease
Description
ADAMTS14, also known as ADAM metallopeptidase with thrombospondin type 1 motif, 14, is a secreted extracellular matrix (ECM) protease that belongs to the ADAMTS family. It is a multi-domain protein with a signal peptide, a prodomain, a metalloprotease domain, a disintegrin-like domain, and a thrombospondin-1-like domain. ADAMTS14 is involved in a wide range of biological processes, including ECM remodeling, cell migration, angiogenesis, and inflammation.
Associated Diseases
ADAMTS14 has been implicated in several human diseases, including:
- Cartilage osteoarthritis (OA): ADAMTS14 is elevated in OA patients and contributes to cartilage degradation by cleaving aggrecan, a major ECM component of cartilage.
- Intervertebral disc disease (IDD): ADAMTS14 levels are increased in IDD and may play a role in disc degeneration.
- Cancer: ADAMTS14 is overexpressed in various cancers, where it promotes tumor growth, invasion, and angiogenesis.
- Cardiovascular diseases: ADAMTS14 is involved in vascular remodeling and has been associated with atherosclerosis and hypertension.
- Neurodegenerative disorders: ADAMTS14 is dysregulated in Alzheimer‘s disease and multiple sclerosis, where it contributes to neuroinflammation and neuronal damage.
Did you Know ?
According to a study published in Nature Medicine, ADAMTS14 levels are significantly elevated in the synovial fluid of patients with OA compared to healthy controls. This elevation correlates with increased cartilage degradation and disease severity.
