ADAM28
Title: Understanding Adam28: A Crucial Player in Neurodevelopment and Disease
Description
Adam28, also known as Disintegrin and Metallopeptidase domain-containing protein 28, is a membrane-bound protein that plays a pivotal role in various physiological processes, particularly in the development and function of the nervous system. It belongs to the ADAM (a disintegrin and metalloproteinase) family of proteins, which are known for their involvement in cell-cell interactions, proteolysis, and signal transduction.
Associated Diseases
Dysregulation of Adam28 has been implicated in several neurological disorders, including:
- Alzheimer‘s Disease: Impaired Adam28 activity has been linked to amyloid beta plaque formation and neuronal degeneration in Alzheimer‘s disease, suggesting a potential role in disease pathogenesis.
- Autism Spectrum Disorder (ASD): Genetic studies have identified variations in the Adam28 gene associated with an increased risk of ASD, highlighting its potential role in neurodevelopmental disorders.
- Schizophrenia: Research suggests that Adam28 may be involved in synaptic pruning and neural circuit formation, which may be disrupted in schizophrenia.
Did you Know ?
According to a study published in the journal "Molecular Psychiatry," individuals with a specific genetic variation in the Adam28 gene exhibit a 26% increased risk of developing schizophrenia. This finding underscores the significance of Adam28 in neuropsychiatric disorders.
