ADAM10
ADAM10: A Key Protease with Diverse Roles in Health and Disease
Description
ADAM10 (A Disintegrin And Metalloproteinase 10) is a type I transmembrane protein belonging to the ADAM (A Disintegrin And Metalloenzyme) family. It is a protease, an enzyme that cleaves other proteins, and plays a crucial role in various cellular processes. ADAM10 is found on the surface of cells and is involved in interactions with the extracellular matrix and other cell surface proteins.
Associated Diseases
ADAM10 has been implicated in several human diseases, including:
- Alzheimer‘s disease: ADAM10 is involved in the processing of amyloid precursor protein (APP), which can lead to the formation of amyloid plaques in the brain, a hallmark of Alzheimer‘s disease.
- Cancer: ADAM10 has been shown to promote tumor growth and metastasis in various cancers, including breast, lung, and colon cancer.
- Cardiovascular disease: ADAM10 is involved in the regulation of blood vessel formation and function, and its dysfunction has been linked to the development of cardiovascular diseases such as atherosclerosis and heart failure.
- Inflammatory diseases: ADAM10 is involved in the activation of inflammatory signaling pathways, and its dysregulation has been implicated in chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
Did you Know ?
ADAM10 is estimated to cleave over 150 different protein substrates, making it one of the most promiscuous proteases in the human body.
