ACTR3B

Description

The ACTR3B (actin related protein 3B) is a protein-coding gene located on chromosome 7.

ACTR3B is a human gene that encodes for Actin-related protein 3B, also known as ARP3-beta. It is part of the actin-related protein (ARP) family, sharing 35-55% amino acid similarity with conventional actin. This protein plays a potential regulatory role in the actin cytoskeleton, possibly influencing cell shape changes and motility. The gene has multiple transcript variants and protein isoforms due to alternative splicing. Pseudogenes are located on chromosomes 2, 4, 10, 16, 22 and Y.

ACTR3B, also known as ARP3-beta, is a key player in the organization of the actin cytoskeleton. It acts as an ATP-binding component within the Arp2/3 complex, which regulates actin polymerization. This complex, in conjunction with an activating nucleation-promoting factor (NPF), promotes the formation of branched actin networks. Interestingly, ACTR3B may also play a role in reducing the metastatic potential of tumors.

ACTR3B is also known as ARP11, ARP3BETA.

Associated Diseases


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