ACSL3
A Comprehensive Guide to ACSL3: Associated Diseases, Statistics, and Latest Research
Description
Acyl-CoA synthetase long-chain family member 3 (ACSL3) is an enzyme involved in the activation of long-chain fatty acids. It plays a crucial role in energy metabolism, lipid synthesis, and cellular signaling. ACSL3 is highly expressed in various tissues, including the liver, heart, muscle, and brain.
Associated Diseases
Dysregulation of ACSL3 has been linked to several diseases, including:
- Obesity: ACSL3 overexpression contributes to increased fatty acid uptake and storage, leading to obesity and insulin resistance.
- Type 2 Diabetes: ACSL3 inhibition improves glucose metabolism and reduces insulin resistance in animal models of type 2 diabetes.
- Cardiovascular Disease: ACSL3 deficiency leads to impaired fatty acid oxidation in the heart, increasing the risk of heart failure.
- Neurodegenerative Diseases: ACSL3 dysfunction has been implicated in the pathogenesis of neurodegenerative diseases such as Alzheimer‘s disease and Parkinson‘s disease.
Did you Know ?
According to a recent study, individuals with a genetic variant in the ACSL3 gene have a significantly increased risk of developing obesity and insulin resistance.
