ACPP
Description
The ACPP gene provides instructions for making the enzyme tartrate-resistant acid phosphatase (TRAP), a crucial factor in bone remodeling. TRAP plays a vital role in bone resorption, the process where old bone is broken down by osteoclasts, cells that are essential for bone maintenance and repair. TRAP is also involved in immune system function and may contribute to the growth and spread of cancer cells.
Associated Diseases
- Hypophosphatasia (HPP): This rare genetic disorder affects bone mineralization due to a deficiency in TRAP activity. Symptoms range from mild to severe, including rickets, osteomalacia, and premature tooth loss.
- Paget's disease of bone: Characterized by abnormal bone turnover and enlargement, Paget's disease is linked to increased TRAP activity.
- Cancer: Some studies suggest that TRAP may contribute to the growth and spread of certain types of cancer.
- Immune disorders: TRAP's involvement in immune responses suggests a possible link to immune-related diseases.
Did you know?
TRAP is named after its ability to break down organic phosphates in the presence of tartrate, a substance found in grapes.
