ACOT13
Description
The ACOT13 gene, also known as acyl-CoA thioesterase 13, plays a vital role in lipid metabolism by hydrolyzing acyl-CoA esters. This process is crucial for various cellular functions, including fatty acid oxidation, phospholipid synthesis, and cholesterol metabolism. ACOT13 is expressed in diverse tissues, including the liver, brain, and adipose tissue, highlighting its broad involvement in lipid homeostasis.
Associated Diseases
- Metabolic Disorders: Non-alcoholic fatty liver disease (NAFLD):Mutations in ACOT13 have been linked to increased risk of NAFLD and its progression to non-alcoholic steatohepatitis (NASH).
- Obesity:Studies suggest that altered ACOT13 expression or activity might contribute to obesity development.
- Dyslipidemia: ACOT13 dysfunction can impact lipid profiles, leading to dyslipidemia, characterized by abnormal levels of cholesterol, triglycerides, and other lipids in the blood.
- Neurological Disorders:Neurodevelopmental disorders:Emerging evidence implicates ACOT13 in neurodevelopment, and its dysregulation might be associated with certain neurodevelopmental disorders.
Did you know?
ACOT13 is a highly conserved gene, meaning its sequence and function have been maintained throughout evolution, indicating its importance for cellular processes.
