ACKR1
ACKR1: A Versatile Receptor with Diverse Roles in Human Health
Description
ACKR1 (Atypical Chemokine Receptor 1), also known as CXCR7, is a G-protein-coupled receptor (GPCR) that plays a crucial role in various physiological processes. Unlike typical chemokine receptors that are activated by specific chemokines, ACKR1 binds to multiple ligands, including chemokines, atypical ligands, and viral proteins.
This unique ligand-binding profile enables ACKR1 to regulate a wide range of cellular functions, including chemotaxis, inflammation, angiogenesis, and cell migration.
Associated Diseases
ACKR1 has been implicated in the pathogenesis of several diseases, including:
- Cancer: ACKR1 overexpression has been observed in various cancers, where it promotes tumor growth, angiogenesis, and metastasis.
- Immune disorders: ACKR1 plays a role in regulating immune cell function, and its dysfunction has been linked to inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
- Cardiovascular diseases: ACKR1 is involved in the regulation of vascular tone and inflammation, and its dysregulation contributes to cardiovascular diseases such as atherosclerosis and hypertension.
- Neurological disorders: ACKR1 has been implicated in the development and pathogenesis of neurodegenerative diseases, including Alzheimer‘s and Parkinson‘s diseases.
Did you Know ?
ACKR1 is expressed in over 100 different cell types and tissues in the human body, highlighting its diverse role in various physiological processes.
