ACIN1
ACIN1: A Gene Linked to Alzheimer‘s Disease and Beyond
Description
Apolipoprotein C-I (APOC-I), also known as ACIN1, is a gene located on chromosome 19. It encodes the protein apolipoprotein C-I, which is a component of high-density lipoprotein (HDL) particles. HDL particles are responsible for transporting cholesterol out of the body, and low levels of HDL are associated with an increased risk of cardiovascular disease.
Associated Diseases
Mutations in the ACIN1 gene have been linked to a number of diseases, including:
- Alzheimer‘s disease (AD): ACIN1 is one of the strongest genetic risk factors for late-onset AD, which is the most common form of dementia.
- Cardiovascular disease (CVD): ACIN1 mutations have been linked to an increased risk of CVD, including heart attack and stroke.
- Type 2 diabetes: ACIN1 mutations have been linked to an increased risk of type 2 diabetes.
- Age-related macular degeneration (AMD): ACIN1 mutations have been linked to an increased risk of AMD, which is the leading cause of blindness in people over 50.
Did you Know ?
In a study of over 1,000 people with AD, researchers found that those with a mutation in the ACIN1 gene were more than twice as likely to develop the disease than those without the mutation.
