ACAD10
Description
The ACAD10 (acyl-CoA dehydrogenase family member 10) is a protein-coding gene located on chromosome 12.
ACAD10 is a human gene encoding a protein belonging to the acyl-CoA dehydrogenase (ACAD) family. ACADs are involved in the beta-oxidation of fatty acids within mitochondria. The ACAD10 protein features a hydrolase domain at the N-terminus, a serine/threonine protein kinase catalytic domain in the central region, and a conserved ACAD domain at the C-terminus. Multiple transcript variants of ACAD10 have been identified, but the full-length nature of some remains unclear. In Pima individuals, ACAD10 has been linked to type 2 diabetes, insulin resistance, and impaired lipid metabolism. Two specific single nucleotide polymorphisms (SNPs), rs601663 and rs659964, exhibit strong correlations with these conditions within a significant population of Pima individuals and American Indians. Using affinity capture mass spectrometry, ACAD10 has been shown to interact with several proteins, including P2RY8, NDUFA10, NTRK3, SLC2A12, LPAR4, PTH1R, COLEC10, APP, MAS1, CD79A, BSG, and Ubiquitin C.
ACAD10 is also known as -.
