ABR
Description
The ABR (ABR activator of RhoGEF and GTPase) is a protein-coding gene located on chromosome 17.
ABR or ABR can refer to various things, including a gene and a protein.
ABR protein exhibits dual regulatory roles on small GTP-binding proteins. Its C-terminal GTPase-activating protein (GAP) domain promotes GTP hydrolysis by RAC1, RAC2, and CDC42, decreasing their active GTP-bound form. Conversely, the central Dbl homology (DH) domain acts as a guanine nucleotide exchange factor (GEF), facilitating the conversion of CDC42, RHOA, and RAC1 from inactive GDP-bound to active GTP-bound forms. ABR is a key negative regulator of neuronal RAC1 activity, and influences macrophage functions such as CSF-1-directed motility and phagocytosis by regulating RAC1 activity. It interacts with DLG4. (Evidence: UniProtKB:Q5SSL4, PubMed:17116687, PubMed:7479768)
ABR is also known as MDB.
