ABHD14B


ABHD14B

Description

ABHD14B (Abhydrolase Domain Containing 14B) is an enzyme that plays a crucial role in lipid metabolism and has been linked to several diseases. It belongs to the alpha/beta-hydrolase superfamily and is primarily responsible for hydrolyzing N-acylphosphatidylethanolamines (NAPEs). NAPEs are lipid molecules that regulate various physiological processes, including inflammation, pain, and appetite control.

Associated Diseases

Impairments in ABHD14B function have been implicated in the following diseases:

  • Obesity: ABHD14B deficiency leads to increased appetite and weight gain in mice. Studies suggest that it may also contribute to obesity in humans.
  • Diabetes: ABHD14B plays a role in glucose homeostasis. Mutations in the ABHD14B gene have been associated with insulin resistance and impaired glucose tolerance.
  • Neurodegenerative diseases: ABHD14B is expressed in the brain and may be involved in neuroprotection. Reduced ABHD14B levels have been observed in Alzheimer‘s disease and Parkinson‘s disease.
  • Inflammatory diseases: ABHD14B regulates the production of lipid mediators involved in inflammation. Its dysfunction has been linked to chronic inflammatory conditions such as asthma and arthritis.

Did you Know ?

A study conducted by researchers at the University of California, San Francisco, found that individuals with a specific genetic variant in the ABHD14B gene had a 30% lower risk of developing type 2 diabetes compared to those without the variant.



Disclaimer: The information provided here is not exhaustive by any means. Always consult your doctor or other qualified healthcare provider with any questions you may have regarding a medical condition, procedure, or treatment, whether it is a prescription medication, over-the-counter drug, vitamin, supplement, or herbal alternative.