ABCG1


Description

Name: ABCG1 (ATP-binding cassette sub-family G member 1)

Function: ABCG1 is a transmembrane protein involved in the transport of various molecules across cellular membranes. It plays a crucial role in drug resistance, cellular detoxification, and lipid homeostasis.

Associated Diseases

1. Cancer: ABCG1 is associated with drug resistance in various cancers, including:

  • Breast cancer
  • Lung cancer
  • Colon cancer
  • Leukemia

2. Cholestasis: ABCG1 is involved in the transport of bile salts, and mutations in this gene can lead to cholestasis, a condition characterized by impaired bile flow.

3. Crohn‘s Disease: ABCG1 has been implicated in the development of Crohn‘s disease, an inflammatory bowel disease.

4. Immunodeficiency: Mutations in ABCG1 can result in immunodeficiency disorders, such as X-linked severe combined immunodeficiency (XSCID).

Did you Know ?

Approximately 2-5% of breast cancer patients exhibit elevated levels of ABCG1, which is associated with poor treatment outcomes and reduced survival rates.


Disclaimer: The information provided here is not exhaustive by any means. Always consult your doctor or other qualified healthcare provider with any questions you may have regarding a medical condition, procedure, or treatment, whether it is a prescription medication, over-the-counter drug, vitamin, supplement, or herbal alternative.