ABCC1


abcc1: A Membrane Transporter with Diverse Roles in Health and Disease

Description

ABCC1, also known as the multidrug resistance-associated protein 1 (MRP1), is a membrane transporter protein that plays a crucial role in cellular detoxification and drug resistance. It belongs to the ATP-binding cassette (ABC) superfamily of proteins, which utilize energy from ATP hydrolysis to transport various substrates across cellular membranes. ABCC1 is primarily expressed in the liver, kidneys, and blood-brain barrier, where it transports a wide range of molecules, including drugs, metabolites, and toxins.

Associated Diseases

Dysregulation of ABCC1 activity has been linked to several diseases, including:

  • Cancer: ABCC1 contributes to drug resistance in cancer cells by actively effluxing chemotherapeutic agents. Overexpression of ABCC1 has been associated with poor prognosis in various malignancies.
  • Liver disease: Mutations in the ABCC1 gene can lead to progressive familial intrahepatic cholestasis (PFIC), a rare genetic disorder characterized by impaired bile flow and liver damage.
  • Kidney disease: ABCC1 plays a role in the excretion of toxins and metabolic waste products from the kidneys. Reduced expression or activity of ABCC1 can contribute to kidney dysfunction and disease.
  • Neurological disorders: ABCC1 transports various compounds that are essential for brain function. Alterations in ABCC1 activity have been implicated in the pathogenesis of Alzheimer‘s disease and other neurodegenerative disorders.

Did you Know ?

ABCC1 is responsible for the efflux of approximately 40% of clinically used drugs, highlighting its significant role in drug resistance and pharmacokinetics.


Disclaimer: The information provided here is not exhaustive by any means. Always consult your doctor or other qualified healthcare provider with any questions you may have regarding a medical condition, procedure, or treatment, whether it is a prescription medication, over-the-counter drug, vitamin, supplement, or herbal alternative.